Efficacy Analysis
dataAdasCog11 <- subset(dataAll$ADQSADAS, PARAMCD == "ACTOT")
dataCIBIC <- subset(dataAll$ADQSCIBC, PARAMCD == "CIBICVAL")
dataEfficacy <- plyr::rbind.fill(dataAdasCog11, dataCIBIC)
dataEfficacy$TRTP <- with(dataEfficacy, reorder(TRTP, TRTPN))
dataEfficacy$AVISIT <- with(dataEfficacy, reorder(AVISIT, AVISITN))
stats <- getStatsData(
data = dataEfficacy,
var = c("AVAL", "CHG"),
type = c("n", "mean (se)", "median (range)")
)
getSummaryStatisticsTable(
data = dataEfficacy,
rowVar = "PARAM",
colVar = c("TRTP", "AVISIT"),
var = c("AVAL", "CHG"),
stats = stats,
labelVars = labelVars,
title = paste("Table: efficacy endpoints",
toTitleCase("actual value and changes from baseline per time point"
))
# file = file.path("tables_CSR", "Table_efficacy.docx")
)
Table: efficacy endpoints Actual Value and Changes from Baseline per Time Point | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Parameter | Placebo | Xanomeline Low Dose | Xanomeline High Dose | |||||||||
Variable | ||||||||||||
Statistic | Baseline | Week 8 | Week 16 | Week 24 | Baseline | Week 8 | Week 16 | Week 24 | Baseline | Week 8 | Week 16 | Week 24 |
Adas-Cog(11) Subscore | ||||||||||||
Analysis Value | ||||||||||||
n | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 3 | 3 | 3 |
Mean (SE) | 14.0 (6.00) | 16.5 (3.50) | 17.5 (2.50) | 17.5 (2.50) | 32.0 (23.00) | 37.0 (25.00) | 38.5 (23.50) | 37.0 (25.00) | 15.7 (6.36) | 16.7 (6.36) | 15.3 (5.21) | 17.7 (5.36) |
Median (range) | 14.0 (8,20) | 16.5 (13,20) | 17.5 (15,20) | 17.5 (15,20) | 32.0 (9,55) | 37.0 (12,62) | 38.5 (15,62) | 37.0 (12,62) | 15.0 (5,27) | 16.0 (6,28) | 16.0 (6,24) | 22.0 (7,24) |
Change from Baseline | ||||||||||||
n | - | 2 | 2 | 2 | - | 2 | 2 | 2 | - | 3 | 3 | 3 |
Mean (SE) | - | 2.5 (2.50) | 3.5 (3.50) | 3.5 (3.50) | - | 5.0 (2.00) | 6.5 (0.50) | 5.0 (2.00) | - | 1.0 (0.00) | -0.3 (1.33) | 2.0 (2.89) |
Median (range) | - | 2.5 (0,5) | 3.5 (0,7) | 3.5 (0,7) | - | 5.0 (3,7) | 6.5 (6,7) | 5.0 (3,7) | - | 1.0 (1,1) | 1.0 (-3,1) | 2.0 (-3,7) |
CIBIC Score | ||||||||||||
Analysis Value | ||||||||||||
n | - | 1 | 1 | 1 | - | 2 | 2 | 2 | - | 2 | 3 | 3 |
Mean (SE) | - | 6.0 ( NA) | 5.0 ( NA) | 5.0 ( NA) | - | 5.0 (0.00) | 4.5 (0.50) | 4.5 (0.50) | - | 4.5 (0.50) | 4.0 (0.00) | 4.3 (0.33) |
Median (range) | - | 6.0 (6,6) | 5.0 (5,5) | 5.0 (5,5) | - | 5.0 (5,5) | 4.5 (4,5) | 4.5 (4,5) | - | 4.5 (4,5) | 4.0 (4,4) | 4.0 (4,5) |